The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia risk.
Qiuman LiangYi JiangAnnie W ShiehDan ZhouRui ChenFeiran WangMeng XuMingming NiuXusheng WangDalila PintoYue WangLijun ChengRamu VadukapuramChunling ZhangKay GrennanGina Giasenull nullKevin P WhiteJunmin PengBingshan LiYanling LiuChao ChenSidney H WangPublished in: bioRxiv : the preprint server for biology (2023)
The effect of eQTLs on gene expression in the prefrontal cortex is commonly attenuated post-transcriptionally. Many of the attenuated eQTLs still correlate with SCZ GWAS signal. Further investigation is needed to elucidate a mechanistic link between attenuated eQTLs and SCZ disease risk.