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The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia risk.

Qiuman LiangYi JiangAnnie W ShiehDan ZhouRui ChenFeiran WangMeng XuMingming NiuXusheng WangDalila PintoYue WangLijun ChengRamu VadukapuramChunling ZhangKay GrennanGina Giasenull nullKevin P WhiteJunmin PengBingshan LiYanling LiuChao ChenSidney H Wang
Published in: bioRxiv : the preprint server for biology (2023)
The effect of eQTLs on gene expression in the prefrontal cortex is commonly attenuated post-transcriptionally. Many of the attenuated eQTLs still correlate with SCZ GWAS signal. Further investigation is needed to elucidate a mechanistic link between attenuated eQTLs and SCZ disease risk.
Keyphrases
  • gene expression
  • prefrontal cortex
  • dna methylation
  • bipolar disorder
  • copy number
  • genome wide association study