Brain Health in Children with Type 1 Diabetes: Risk and Protective Factors.
Sarah S JaserLori C JordanPublished in: Current diabetes reports (2021)
Emerging evidence suggests that hyperglycemia and time in range may be more important for brain development than episodes of hypoglycemia. Further, diabetic ketoacidosis (DKA) at the time of T1D diagnosis appears to be a particular risk factor for neurocognitive complications, particularly deficits in executive function skills and memory, with differences in cerebral white matter microstructure seen via advanced magnetic resonance imaging methods, and lower scores on measures of attention and memory observed among children who were diagnosed in DKA. Other factors that may influence neurocognitive development include child sleep, caregiver distress, and diabetes device use, presumably due to improved glycemic control. We highlight neurocognitive risk and protective factors for children with T1D and priorities for future research in this high-risk population.
Keyphrases
- white matter
- glycemic control
- type diabetes
- magnetic resonance imaging
- young adults
- working memory
- multiple sclerosis
- healthcare
- blood glucose
- public health
- cardiovascular disease
- mental health
- bipolar disorder
- computed tomography
- traumatic brain injury
- resting state
- risk factors
- cerebral ischemia
- health information
- subarachnoid hemorrhage
- metabolic syndrome
- magnetic resonance
- skeletal muscle
- blood brain barrier
- sleep quality
- contrast enhanced
- medical students
- social media
- oxidative stress
- depressive symptoms
- diabetic rats