Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy.

Robyn V BroadStacey J JonesMelina C TeskeLaura M WastallAndrew M HanbyJames L Thorne Thomas A Hughes

Published in: British journal of cancer (2021)

CAF-induced activation of IFN signalling in claudin-low TNBCs results in chemoresistance. Inhibition of this pathway represents a novel method to improve breast cancer outcomes.

Keyphrases

dendritic cells
high glucose
immune response
type diabetes
squamous cell carcinoma
metabolic syndrome
locally advanced
endothelial cells
insulin resistance
skeletal muscle
childhood cancer
wound healing
weight loss