RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment.

Han-Hee ParkHwa-Ryeon KimSang-Yeong ParkSung-Min HwangSun Mi HongSangwook ParkHo Chul KangMichael J MorganJong-Ho ChaDakeun LeeJae-Seok RoeYou-Sun Kim

Published in: Molecular cancer (2021)

Our data suggest that RIPK3 activation-dependent derepression of TRIM28 in cancer cells leads to increased immunostimulatory cytokine production in the tumor microenvironment, which then contributes to robust cytotoxic anti-tumor immunity.

Keyphrases

electronic health record
big data
machine learning
data analysis
artificial intelligence