Loss-of-function mutation in Pcsk1 increases serum APOA1 level and LCAT activity in mice.

Aleksandra Aljakna KhanNakyung KimRon KorstanjeSeungbum Choi

Published in: Laboratory animal research (2022)

This study presents the first evaluation of the role of PCSK1 in HDL metabolism using a loss-of-function mutant mouse model. Further investigations will be needed to determine the underlying molecular mechanism.

Keyphrases

mouse model
wild type
high fat diet induced
low density lipoprotein
insulin resistance
skeletal muscle