Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study.

Camille ManéClément DelmasJean PorterieGéraldine JourdanPatrick VerwaerdeBertrand MarcheixDidier ConcordetBernard GeorgesStéphanie RuizPeggy Gandia

Published in: Journal of translational medicine (2020)

Considering that the influence of ECMO on the pharmacokinetics of ceftolozane/tazobactam is not clinically significant, normal ceftolozane and tazobactam dosing in critically ill patients should be effective for patients undergoing ECMO.

Keyphrases

extracorporeal membrane oxygenation
gram negative
acute respiratory distress syndrome
multidrug resistant
patients undergoing
respiratory failure
mechanical ventilation