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Intracerebroventricular Injection of MHY1485 Blocked the Beneficial Effect of Adiponectin on Aversive Memory in the STZ Model of Dementia.

Samira RashtianiIran GoudarziAdele JafariKambiz Rohampour
Published in: Central nervous system agents in medicinal chemistry (2023)
In a rat model of AD, we found that adiponectin improved aversive and cognitive memory, which is at least partially mediated by the mTOR signaling cascade.
Keyphrases
  • metabolic syndrome
  • working memory
  • insulin resistance
  • mild cognitive impairment
  • cell proliferation
  • cognitive impairment
  • diabetic rats
  • type diabetes
  • skeletal muscle
  • oxidative stress