Protective Role of Glutathione and Nitric Oxide Production in the Pathogenesis of Pterygium.
Fidelina ParraAlexandre Kormanovski-KovzovaGustavo Guevara-BalcazarMaría Del Carmen Castillo-HernándezAntonio Franco-VadilloMireille Toledo-BlasRosa Adriana Jarillo-LunaEleazar Lara-PadillaPublished in: Journal of ophthalmology (2020)
The results are congruent with the following proposed sequence of events leading to a protective response of the organism during the pathogenesis of primary pterygium: a decreased level of eNOS provokes a decline in the level of NO in pterygium tissue, which then leads to reduced S-nitrosylation of GSH or other thiols and possibly to the modulation of the intracellular level of GSH through synthesis and/or mobilization from other tissues.