The Effect of Intrahippocampal Insulin Injection on Scopolamine-induced Spatial Memory Impairment and Extracellular Signal-regulated Kinases Alteration.

Ahmad Jahanmahin Zahra Abbasnejad Abbas Haghparast Abolhassan Ahmadiani Rasoul Ghasemi

Published in: Basic and clinical neuroscience (2019)

Insulin as a neuroprotective agent cannot restore memory when there is no hippocampal damage. In addition, the neuromodulator effect of insulin is not potent enough to overwhelm scopolamine-mediated disruptions of synaptic neurotransmission.

Keyphrases

type diabetes
glycemic control
working memory
cerebral ischemia
oxidative stress
diabetic rats
high glucose
transcription factor
drug induced
ultrasound guided
insulin resistance
subarachnoid hemorrhage
prefrontal cortex
stress induced
temporal lobe epilepsy