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Chronic low-grade inflammation in heart failure with preserved ejection fraction.

Thássio Ricardo R MesquitaYen-Nien LinAhmed Ibrahim
Published in: Aging cell (2021)
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form of HF with a dramatic increase in risk with age. Low-grade inflammation, as occurs with aging (termed "inflammaging"), is a common feature of HFpEF pathology. Suppression of proinflammatory pathways has been associated with attenuated HFpEF disease severity and better outcomes. From this perspective, inflammasome signaling plays a central role in mediating chronic inflammation and cardiovascular disease progression. However, the causal link between the inflammasome-immune signaling axis on the age-dependent progression of HFpEF remains conjectural. In this review, we summarize the current understanding of the role of inflammatory pathways in age-dependent cardiac function decline. We will also evaluate recent advances and evidence regarding the inflammatory pathway in the pathophysiology of HFpEF, with special attention to inflammasome signaling.
Keyphrases
  • low grade
  • oxidative stress
  • high grade
  • ejection fraction
  • heart failure
  • acute heart failure
  • deep learning
  • working memory
  • coronary artery disease
  • atrial fibrillation