Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.

Sheng-Chieh LinYi-Chu LiaoPo-Ming ChenYa-Yu YangYi-Hsiang WangShiao-Lin TungChi-Mu ChuangYu-Wen SungTe-Hsuan JangShuang-En ChuangLu-Hai Wang

Published in: Journal of biomedical science (2022)

Our study revealed a POSTN-integrin-NF-κB-mediated signaling and its involvement in enhancing M2 macrophages and CAFs, which could potentially participate in promoting tumor growth. Our results suggest that POSTN could be a useful prognosis marker and potential therapeutic target.

Keyphrases

signaling pathway
lps induced
pi k akt
nuclear factor
oxidative stress
transforming growth factor
cell adhesion
cell migration
single cell
epithelial mesenchymal transition
cell proliferation
immune response