ZY15557, a novel, long acting inhibitor of dipeptidyl peptidase-4, for the treatment of Type 2 diabetes mellitus.
Mukul R JainAmit A JoharapurkarSamadhan G KshirsagarVishal J PatelRajesh H BahekarHarilal V PatelPradip A JadavPankaj R PatelRanjit C DesaiPublished in: British journal of pharmacology (2017)
ZY15557 is a potent, competitive and long acting DPP-4 inhibitor. ZY15557 showed similar DPP-4 inhibition across different species. ZY15557 showed excellent oral bioavailability in preclinical species. It showed a low plasma clearance (CL) and large volume of distribution (Vss ) across species, resulting in an extended half-life.