Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019.

Priscila Mayrelle da Silva CastanhaDylan J TuttleGeorgios D KitsiosJana L JacobsUlisses Braga-NetoMatthew DuespohlSanjay RathodMichelle M MartiSarah E WheelerAsma NaqviBrittany StainesJohn MellorsAlison MorrisBryan J McVerryFaraaz ShahCaitlin SchaeferBernard J C MacatangayBarbara MetheChristian A FernandezSimon M Barratt-BoyesDonald BurkeErnesto T A Marques

Published in: The Journal of infectious diseases (2022)

These findings indicate that early, nonneutralizing IgG responses may play a key role in complement overactivation in severe COVID-19. Our work underscores the urgent need to develop therapeutic strategies to modify complement overactivation in patients with COVID-19.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
early onset
drug induced