Low pre-ART CD4 count is associated with increased risk of clinical progression or death even after reaching 500 CD4 cells/μL on ART.

Nikos PanatzisVasilios PaparizosVasilios PapastamopoulosSimeon MetallidisAnastasia AntoniadouGeorgios AdamisMina PsichgiouMaria ChiniHelen SambatakouGeorgios ChrysosNikolaos V SipsasCharalambos GogosEmmanouil BarbunakisPeriklis PanagopoulosOlga KatsarouGiota Toulouminull null

Published in: PloS one (2023)

Individuals starting ART with <200 cells/μL remain on increased risk even after reaching 500 CD4 cells/μL. These patients should be closely followed.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
ejection fraction
endoplasmic reticulum stress
antiretroviral therapy
cell death
peripheral blood