Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol.

Yasuyuki KimuraJ MaedaM YamadaK TakahataK YokokawaY IkomaC SekiH ItoM HiguchiT Suhara

Published in: Psychopharmacology (2016)

A subtle alteration in the state of consciousness was detected with a correlation to the changes in the [11C]raclopride binding, which implies that a subtle alteration in extracellular dopamine concentration in the limbic striatum by a small amount of dopamine transporter occupancy can affect the state of consciousness. TRIAL REGISTRATION HTTPS://UPLOAD.UMIN.AC.JP/CGI-OPEN-BIN/CTR_E/CTR_VIEW.CGI?RECPTNO=R000009703 : UMIN000008232.

Keyphrases

uric acid
prefrontal cortex
clinical trial
study protocol
minimally invasive
physical activity
depressive symptoms
binding protein
sleep quality