Prognostic Value of Low-Pass Whole Genome Sequencing of Circulating Tumor DNA in Metastatic Castration-Resistant Prostate Cancer.
Maibritt NørgaardMarianne T BjerreJacob FredsøeSøren VangJørgen B JensenBram De LaereHenrik GrönbergMichael BorreJohan LindbergKarina Dalsgaard SørensenPublished in: Clinical chemistry (2023)
LPWGS of ctDNA provides clinically relevant information about the tumor genome in mCRPC patients. Using LPWGS data, we show that high ctDNA% and CNA burden at baseline is associated with short PFS and OS in 2 independent cohorts.
Keyphrases
- circulating tumor
- cell free
- circulating tumor cells
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- squamous cell carcinoma
- small cell lung cancer
- prognostic factors
- electronic health record
- peritoneal dialysis
- gene expression
- machine learning
- genome wide
- risk factors
- big data
- patient reported outcomes
- single molecule