Preclinical platform for long-term evaluation of immuno-oncology drugs using hCD34+ humanized mouse model.
Nahee ParkKamal PandeySei Kyung ChangAh-Young KwonYoung Bin ChoJin HurNar Bahadur KatwalSeung Ki KimSeung Ah LeeGun Woo SonJong Min JoHee Jung AhnYong Wha MoonPublished in: Journal for immunotherapy of cancer (2021)
Our CD34+ humanized mouse model is the first in vivo platform for testing the long-term efficacy of anticancer immunotherapies and biomarkers, given that none of the preclinical models has ever been evaluated for such a long duration.