Physiologically Based Pharmacokinetic Model of Brain Delivery of Plasma Protein Bound Drugs.

Published in: Pharmaceutical research (2023)

In vitro measurement of free drug concentration in plasma under-estimates the free drug in brain in vivo if PMU in vivo from either the albumin and/or the AGP pools in plasma takes place at the BBB surface.

Keyphrases

white matter
resting state
blood brain barrier
cerebral ischemia
multiple sclerosis
emergency department
adverse drug
electronic health record