Developmental origins and transgenerational inheritance of polycystic ovary syndrome.
Jim ParkerClaire O'BrienFelice L GershPublished in: The Australian & New Zealand journal of obstetrics & gynaecology (2021)
The current evidence suggests that developmental epigenetic programming following exposure to an adverse maternal metabolic and endocrine environment contributes to the pathogenesis of PCOS. Lifestyle interventions, as recommended by the International Guidelines, have the potential to reduce both symptoms and transgenerational transmission of PCOS.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- physical activity
- metabolic syndrome
- dna methylation
- gene expression
- cardiovascular disease
- mitochondrial dna
- weight loss
- clinical practice
- pregnancy outcomes
- skeletal muscle
- adipose tissue
- sleep quality
- type diabetes
- pregnant women
- risk assessment
- depressive symptoms
- body mass index
- copy number
- drug induced