Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: A longitudinal, multicenter study.
Thomas MeyerMarie DregerTorsten GrehlUte WeyenDagmar KettemannPatrick WeydtRene GüntherPaul LingorSusanne PetriJan Christoph KochJulian GroßkreutzAnnekathrin RödigerPetra BaumAndreas HermannJohannes PrudloMatthias BoentertJochen H WeishauptWolfgang N LöscherJohannes DorstYasemin KocSarah BernsenIsabell CordtsMaximilian VidovicRobert SteinbachMoritz MetelmannVera E KleinveldJenny NordenAlbert LudolphBertram WalterPeggy SchumannChristoph MünchPéter KörtvélyessyAndré MaierPublished in: European journal of neurology (2024)
This study underscored the correlation of ALS phenotypes - differentiated for motor neuron involvement and region of onset/propagation - with sNfL, progression, and survival. These phenotypes demonstrated a significant effect on sNfL and should be recognized as independent confounders of sNfL analyses in ALS trials and clinical practice.