METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.

Xiaoxue Hou Yuwen Li Jiali Song Linya Peng Wen Zhang Rui Liu Hui Yuan Tiantong Feng Jieying Li Wenting Li Chuanlong Zhu

Published in: Hepatology communications (2023)

METTL14 functioned as a profibrotic gene by suppressing NOVA2 activity in a mechanism dependent on m6A-YTHDF2. Moreover, knocking down METTL14 exacerbated LF, while NOVA2 prevented its development and partly reversed the damage.

Keyphrases

liver fibrosis
oxidative stress
signaling pathway
copy number
genome wide
gene expression