Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis.
Jonathon J GrahamSujit MukherjeeMuhammad YukselRebeca Sanabria MateosTengfei SiZhenlin HuangXiahong HuangHadil Abu ArqoubVishal C PatelMark McPhailYoh ZenNigel HeatonMaria Serena LonghiMichael A HeneghanRodrigo LiberalDiego VerganiGiorgina Mieli-VerganiYun MaBu'Hussain HayeePublished in: Hepatology (Baltimore, Md.) (2021)
These findings refute the widely accepted "gut homing" hypothesis as the primary driver of PSC and indicate that aberrant hepatic recruitment of gut-derived T cells is not unique to PSC, but is a panetiological feature of CLD.