Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease.

C RuffmannN Bengoa-VergnioryI PoggioliniD RitchieM T HuJ Alegre-AbarrateguiLaura Parkkinen

Published in: Neuropathology and applied neurobiology (2018)

Our study suggests that detection of aSyn conformational variants currently considered pathological is not adequate for the diagnosis or prediction of PD. Future studies utilizing novel ultrasensitive amyloid aggregation assays may increase sensitivity and specificity.

Keyphrases

label free
copy number
molecular dynamics
molecular dynamics simulations
loop mediated isothermal amplification
single molecule
real time pcr
gold nanoparticles
high throughput
quantum dots
ultrasound guided
gene expression
fine needle aspiration
high resolution
molecularly imprinted