Validation of eGFR for Detecting Associations Between Serum Protein Biomarkers and Subsequent GFR Decline.

Inger Therese EnoksenNikoline B RindeDmitri SvistounovJon V NorvikMarit D SolbuBjørn Odvar EriksenToralf Melsom

Published in: Journal of the American Society of Nephrology : JASN (2023)

In studies of some serum protein biomarkers, eGFR decline may not be an appropriate surrogate outcome for mGFR decline. Although the differences from mGFR decline are attenuated by adjustment for confounding factors in most cases, some persist. Therefore, proposed biomarkers from studies using eGFR should preferably be validated with mGFR.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
protein protein
case control
binding protein
small molecule