African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.
Rachel MartiniPrincesca DelpeTimothy R ChuKanika S AroraBrittany D LordAkanksha VermaDeepa BediBalasubramanyanam KaranamIsra ElhussinYalei ChenEndale Hadgu GebregzabherJoseph K OppongErnest K AdjeiAisha Jibril SuleimanBaffour AwuahMahteme Bekele MuletaEngida AbebeIshmael KyeiFrances S AitpillahMichael O AdinkuKwasi AnkomahErnest Baawuah Osei-BonsuDhananjay A ChitaleJessica M BensenhaverS David NathansonLaToya JacksonLindsay F PetersenErica ProctorBrian StonakerKofi K GyanLee D GibbsZarko ManojlovicRick A KittlesJason A WhiteClayton C YatesUpender ManneKevin GardnerNigel Patrick MonganEsther ChengPaula S GinterSyed A HodaOlivier ElementoNicolas RobineAndrea SbonerJohn D CarptenLisa A NewmanMelissa B DavisPublished in: Cancer discovery (2022)
Our comprehensive ancestry quantification process revealed that ancestry-associated gene expression profiles in TNBC include population-level distinctions in immunologic landscapes. These differences may explain some differences in race-group clinical outcomes. This study shows the first definitive link between African ancestry and the TNBC immunologic landscape, from an African-enriched international multiethnic cohort. See related commentary by Hamilton et al., p. 2496. This article is highlighted in the In This Issue feature, p. 2483.