Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data.

Hasan Çağın Lenk Robert Løvsletten Smith Kevin Sean O'Connell Ole Andreas Andreassen Espen Molden

Published in: CNS drugs (2024)

LCD and associated rapid metabolism of non-clozapine antipsychotics is frequent before starting clozapine treatment. For olanzapine and quetiapine, this is associated with significantly increased risk of having subtherapeutic concentrations.

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