Use of adjuvant chemotherapy in hormone receptor-positive breast cancer patients with or without the 21-gene expression assay.

Soo Jin ParkMoo Hyun LeeSun-Young KongMi Kyung SongJungnam JooYoungmee KwonEun-Gyeong LeeJai Hong HanSung Hoon SimSo-Youn JungSeeyoun LeeKeun Seok LeeIn Hae ParkEun-Sook Lee

Published in: Breast cancer research and treatment (2018)

For HR-positive, HER2-negative breast cancer patients with 0-1 node metastases, chemotherapy use declined significantly after the adoption of the 21-gene assay. PgR status and Ki-67 were useful for chemotherapy decision-making in cases without the 21-gene assay.

Keyphrases

positive breast cancer
gene expression
high throughput
copy number
genome wide
locally advanced
lymph node
genome wide identification
squamous cell carcinoma
electronic health record
radiation therapy
chemotherapy induced
genome wide analysis