MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria-dependent dephosphorylation of EGFR.

Li LuoDenghui WeiYihui PanQiu-Xia WangJian-Xiong FengBing YuTiebang KangJunhang LuoJiefeng YangSong Gao

Published in: Cancer communications (London, England) (2023)

Our findings uncover an important non-canonical mitochondria-dependent pathway regulating EGFR signaling by the Rab21-MFN2-PTPRJ axis, which contributes to the development of novel therapeutic strategies for ccRCC.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
signaling pathway
cell death
reactive oxygen species
endoplasmic reticulum