SREBP2 maintains glioblastoma stem cells through keeping the balance between cholesterol biosynthesis and uptake.
Danling GuFengqi ZhouHao YouJiancheng GaoTao KangDeobrat DixitQiulian WuKailin YangShusheng CiDanyang ShanXiao FanWei YuanQian ZhangChenfei LuDaqi LiNingwei ZhaoZhumei ShiWei GaoFan LinJianghong ManQianghu WangXu QianStephen C MackWeiwei TaoSameer AgnihotriNu ZhangYongping YouJeremy N RichJunxia ZhangXiuxing WangPublished in: Neuro-oncology (2023)
SREBP2 displays context-specific regulation of cholesterol biology based on its availability in the microenvironment with induction of cholesterol biosynthesis in the tumor core and uptake in the margin, informing a novel treatment strategy for GBM.