Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells.
Sergio P Alpuche-LazcanoMatthew StuibleBassel AkacheAnh T TranJohn KellySabahudin HrapovicAnna RobothamArsalan HaqqaniAlexandra T StarTyler M RennerJulie BlouinJean-Sébastien MaltaisBrian CassKai CuiJae-Young ChoXinyu WangDaria ZoubchenokRenu DudaniDiana DuqueMichael J McCluskieYves DurocherPublished in: Communications medicine (2023)
Our results show that CHO cells are amenable to efficient manufacturing of high titers of a potently immunogenic spike protein-based VLP vaccine antigen.