Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells.

Sergio P Alpuche-LazcanoMatthew StuibleBassel AkacheAnh T TranJohn KellySabahudin HrapovicAnna RobothamArsalan HaqqaniAlexandra T StarTyler M RennerJulie BlouinJean-Sébastien MaltaisBrian CassKai CuiJae-Young ChoXinyu WangDaria ZoubchenokRenu DudaniDiana DuqueMichael J McCluskie Yves Durocher

Published in: Communications medicine (2023)

Our results show that CHO cells are amenable to efficient manufacturing of high titers of a potently immunogenic spike protein-based VLP vaccine antigen.

Keyphrases

induced apoptosis
sars cov
cell cycle arrest

endoplasmic reticulum stress
cell death
oxidative stress

signaling pathway
cell proliferation
coronavirus disease

binding protein
cell therapy