Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelos EvangelouHelen R WarrenDavid Mosen-AnsorenaBorbala MifsudRaha PazokiHe GaoGeorgios NtritsosNiki DimouClaudia P CabreraIbrahim KaramanFu Liang NgMarina EvangelouKatarzyna WitkowskaEvan TzanisJacklyn N HellwegeAyush GiriDigna R Velez EdwardsYan V SunKelly ChoJ Michael GazianoPeter W F WilsonPhilip S TsaoCsaba P KovesdyTonu EskoReedik MägiLili A MilaniPeter AlmgrenThibaud S BoutinStéphanie DebetteJun DingFranco GiulianiniElizabeth G HollidayAnne U JacksonRuifang Li-GaoWei-Yu LinJian'an LuanMassimo ManginoChristopher OldmeadowBram Peter PrinsYong QianMuralidharan SargurupremrajNabi ShahPraveen SurendranSébastien ThériaultNiek VerweijSara M WillemsJing-Hua ZhaoPhillippe AmouyelJohn ConnellRenée de MutsertAlex S F DoneyMartin FarrallCristina MenniAndrew D MorrisRaymond NoordamGuillaume ParéNeil R PoulterDenis C ShieldsAlice V StantonSimon A M ThomGonçalo AbecasisNajaf AminDan E ArkingKristin L AyersCaterina M BarbieriChiara BatiniJoshua C BisTineka BlakeMurielle BochudMichael BoehnkeEric BoerwinkleDorret I BoomsmaErwin P BottingerPeter S BraundMarco BrumatArchie I CampbellHarry CampbellAravinda ChakravartiJohn C ChambersGanesh ChauhanMarina CiulloMassimiliano CoccaFrancis S CollinsHeather J CordellGail DaviesMartin H de BorstEco J C N de GeusIan J DearyJoris DeelenFabiola Del Greco MCumhur Yusuf DemirkaleMarcus DörrGeorg B EhretRoberto ElosuaStefan EnrothAbdullah Mesut ErzurumluogluTeresa FerreiraMattias FrånbergOscar H FrancoIlaria GandinPaolo GaspariniVilmantas GiedraitisChristian GiegerGiorgia GirottoAnuj GoelAlan J GowVilmundur GudnasonXiuqing GuoUlf GyllenstenAnders HamstenTamara B HarrisSarah E HarrisCatharina A HartmanAki Samuli HavulinnaAndrew A HicksEdith HoferAlbert HofmanJouke-Jan HottengaJennifer E HuffmanShih-Jen HwangErik IngelssonAlan JamesRick JansenMarjo-Riitta JarvelinRoby JoehanesÅsa JohanssonAndrew D JohnsonPeter K JoshiPekka JousilahtiJohan Wouter JukemaAntti JulaMika KähönenSekar KathiresanBernard D KeavneyKay-Tee KhawPaul KnektJoanne KnightIvana KolcicJaspal S KoonerSeppo KoskinenKati KristianssonZoltán KutalikMaris LaanMarty LarsonLenore J LaunerBenjamin LehneTerho LehtimäkiDavid C M LiewaldLi LinLars LindCecilia M LindgrenYongMei LiuRuth J F LoosLorna M LopezYingchang LuLeo-Pekka LyytikainenAnubha MahajanChrysovalanto MamasoulaJaume MarrugatJonathan MartenYuri MilaneschiAnna MorganAndrew P MorrisAlanna C MorrisonPeter J MunsonMike A NallsPriyanka NandakumarChristopher P NelsonTeemu NiiranenIlja Maria NolteTeresa NutileAlbertine J OldehinkelBen A OostraPaul F O'ReillyElin OrgSandosh PadmanabhanWalter PalmasAarno PalotieAlison PattieBrenda W J H PenninxMarkus PerolaAnnette PetersOzren PolasekPeter P PramstallerQuang Tri NguyenOlli T RaitakariMeixia RenRainer RettigKenneth RicePaul M RidkerJanina S RiedHarriëtte RieseSamuli RipattiAntonietta RobinoLynda M RoseJerome I RotterIgor RudanDaniela RuggieroYasaman SabaCinzia F SalaVeikko V SalomaaNilesh J SamaniAntti-Pekka SarinReinhold SchmidtHelena SchmidtNick ShrineDavid SiscovickAlbert Vernon SmithHarold SniederSiim SõberRossella SoriceJohn M StarrDavid J StottDavid P StrachanRona J StrawbridgeJohan SundströmMorris A SwertzKent D TaylorAlexander TeumerMartin D TobinMaciej TomaszewskiDaniela TonioloMichela TragliaStella TrompetJaakko TuomilehtoChristophe TzourioAndré G UitterlindenAhmad VaezPeter J van der MostCornelia M van DuijnAnne-Claire VergnaudGermaine C VerwoertVeronique VitartUwe VölkerPeter VollenweiderDragana VuckovicHugh WatkinsSarah H WildGonneke WillemsenJames F WilsonAlan F WrightJie YaoTatijana ZemunikWeihua ZhangJohn Richard AttiaAdam S ButterworthDaniel I ChasmanDavid ConenFrancesco CuccaJohn DaneshCaroline HaywardJoanna M M HowsonMarkku LaaksoEdward G LakattaClaudia LangenbergOlle MelanderDennis O Mook-KanamoriColin Neil Alexander PalmerLorenz RischRobert A ScottRodney J ScottPeter SeverTim D SpectorPim van der HarstNicholas J WarehamEleftheria ZegginiDaniel LevyPatricia B MunroeChristopher Newton-ChehMorris J BrownAndres MetspaluAdriana M HungChristopher J O'DonnellTodd L EdwardsBruce M PsatyJoanna TzoulakiMichael R BarnesLouise V WainPaul ElliottMark J Caulfieldnull nullPublished in: Nature genetics (2018)
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.