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Robustness and innovation along the endocytic route: Lessons from darkness.

Kaela S SingletonVictor Faundez
Published in: The Journal of cell biology (2021)
What mechanisms ensure the loading of a SNARE into a nascent carrier? In this issue, Bowman et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202005173) describe an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-safe to recognize sorting signals in VAMP7, a membrane protein required for fusion to melanosomes. Their observations define one of the first examples of distributed robustness in membrane traffic mechanisms.
Keyphrases
  • air pollution
  • single cell
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