Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo.

Rachida Moussa TariAboudoulatif Diallo Emmanuelle Kouame Phénix AssogbaEssotolom BadjabaissiLawson-Evi PoviBatomayena Bakoma Yao PotchooKokou Tona

Published in: Journal of toxicology (2022)

Sulfadoxine-pyrimethamine decreased egg hatch and caused an increase in embryo and chick mortality as well as a loss in relative chick weight and an increase in relative yolk sac weight. More in-depth studies would be needed on sulfadoxine-pyrimethamine teratogenicity and the benefit/risk ratio of this drug during pregnancy.

Keyphrases

plasmodium falciparum
weight loss
body mass index
physical activity
weight gain
pregnancy outcomes
cardiovascular events
body weight
optical coherence tomography
risk factors
type diabetes
emergency department
case control
coronary artery disease