Systemic treatments and outcomes in CIC-rearranged Sarcoma: A national multi-centre clinicopathological series and literature review.
Elizabeth A ConnollyVivek A BhadriJohnathon WakeKatrina M IngleyJeremy LewinSusie BaeDaniel D WongAnne P LongDavid PryorStephen R ThompsonMadeleine C StrachPeter S GrimisonAnnabelle MaharFiona BonarFiona MacleanAngela HongPublished in: Cancer medicine (2022)
In this series, CIC-rearranged sarcomas affected young adults and had a high incidence of presenting with, or developing, metastatic disease. The prognosis overall was poor. In advanced disease, durable systemic therapy responses were infrequent.