Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial.
Subash Raj SusaiMelanie FöckingDavid MonganMeike HeurichFiona CouttsAlice EgertonTony WhettonInge Winter-van RossumRichard D UnwinThomas A PollakMark WeiserMarion LeboyerDan RujescuJonah F ByrneGeorge W GiffordPaola DazzanNikolaos KoutsoulerisRené S KahnDavid R CotterPhilip McGuirePublished in: Schizophrenia bulletin (2023)
The results demonstrated that the response to antipsychotic treatment might be related to pre-treatment levels of plasma complement and coagulation pathway proteins. This is consistent with independent evidence associating immune dysfunction with the pathophysiology of psychosis. Moreover, these results inform the development of novel therapeutic approaches that target the complement system for psychosis.
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