New benzofuran neolignans with neuroprotective activity from Phyllanthodendron breynioides .
Tong SuMei-Cen PuDi-Kai TangJin-Chen LongFang-Yu YuanAi-Ping YinShu-Qi WuSheng YinGui-Hua TangPublished in: Natural product research (2022)
A pair of undescribed dihydrobenzofuran neolignan enantiomers, (+/-)-phybrenan A ( 1a / 1b ), two new benzofuran neolignans, phybrenan B and C ( 2 and 3 ), along with four known neolignans ( 4 - 7 ) were obtained from the plants of Phyllanthodendron breynioides P. T. Li. The planar structures of all isolates were demonstrated by the analysis of detailed spectroscopic evidence (NMR, HRMS, and IR), and the absolute configurations of novel neolignans were elucidated by combined calculated and experimental ECD data analysis. The neuroprotective activities of all benzofuran neolignans against sodium nitroprusside (SNP)-induced cell death were examined in rat pheochromocytoma PC12 cells. The results exhibited that three compounds ( 4 - 6 ) possessed remarkable neuroprotective activities at 10 µ M, better than the positive drug edaravone.
Keyphrases
- data analysis
- cell death
- cerebral ischemia
- high resolution
- magnetic resonance
- oxidative stress
- molecular docking
- genome wide
- drug induced
- high glucose
- subarachnoid hemorrhage
- emergency department
- mass spectrometry
- dna methylation
- cell proliferation
- gene expression
- blood brain barrier
- capillary electrophoresis
- electronic health record
- endothelial cells
- tandem mass spectrometry
- liquid chromatography