HLA association in MOG-IgG- and AQP4-IgG-related disorders of the CNS in the Dutch population.
Arlette L BruijstensYu Yi M WongDaniëlle E van PeltPieter J E van der LindenGeert W HaasnootRogier Q HintzenFrans H J ClaasRinze Frederik NeuteboomBeatrijs H A WokkePublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
The present study demonstrates differences in the immunogenetic background of MOGAD and AQP4-IgG-positive NMOSD. The strong positive association with HLA-A*01, -B*08, and -DRB1*03 is suggestive of a role of this haplotype in the etiology of AQP4-IgG-positive NMOSD in patients with European ancestry, whereas in MOGAD no evidence was found for any HLA association in these disorders.
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