Molecular MR-Imaging for Noninvasive Quantification of the Anti-Inflammatory Effect of Targeting Interleukin-1β in a Mouse Model of Aortic Aneurysm.

Julia BrangschCarolin ReimannJan Ole KaufmannLisa Christine AdamsDavid OnthankChrista Thöne-ReinekeSimon RobinsonMarco WilkeMichael WellerRebecca BuchholzUwe KarstRene BotnarBernd HammMarcus Richard Makowski

Published in: Molecular imaging (2021)

Molecular-MRI enables the early visualization and quantification of the anti-inflammatory-effects of an IL-1β-inhibitor in a mouse-model of AAAs. Responders and non-responders could be identified early after the initiation of the therapy using molecular-MRI.

Keyphrases

mouse model
contrast enhanced
magnetic resonance imaging
aortic aneurysm
anti inflammatory
single molecule
computed tomography
diffusion weighted imaging