The dual role of CD70 in B-cell lymphomagenesis.
Man NieWeicheng RenXiaofei YeMattias BerglundXianhuo WangKarin FjordénLikun DuYvonne GiannoulaDexin LeiWenjia SuWei LiDongbing LiuJohan LinderothChengyi JiangHuijing BaoWenqi JiangHuiqiang HuangYong HouShida ZhuGunilla EnbladMats JerkemanKui WuHuilai ZhangRose-Marie AminiZhi-Ming LiQiang Pan-HammarströmPublished in: Clinical and translational medicine (2022)
Our findings suggest that CD70 can play a role in either tumour suppression or oncogenesis in DLBCL, likely via distinct immune evasion mechanisms, that is, impairing T cell priming or inducing T cell exhaustion. Characterisation of specific dysfunction of CD70 in DLBCL may thus provide opportunities for the development of novel targeted immuno-therapeutic strategies.
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