Preclinical characterization of a next generation brain permeable, paradox breaker BRAF inhibitor.

Jürgen WichmannCaroline RynnThomas FriessJeannine Petrig-SchafflandMartin KornackerCornelia HandlJasmin EmmeneggerJan EckmannFrank HertingNicolas FrancesDaniel HunzikerDaniela KrummenacherDominik RüttingerAlison RibeiroMarina BacacAlessandro Brigo David S Hewings Reinhard DummerMitchell P LevesqueGabriel Schnetzler Bruno MartoglioJames R BischoffPiergiorgio Pettazzoni

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

The novel BRAFi demonstrates preclinically the potential to outperform available targeted therapies for the treatment of BRAF-mutant tumors, thus supporting its clinical investigation.

Keyphrases

wild type
metastatic colorectal cancer
resting state
cell therapy
brain injury
functional connectivity
cerebral ischemia
subarachnoid hemorrhage