Inverse correlation between age of onset and myocardial amyloid deposition quantified by 99m Tc-PYP scintigraphy in patients with wild-type transthyretin amyloid cardiomyopathy.

The H/CL ratio, Hb, and Cr independently affect age of onset in patients with ATTRwt-CM. The H/CL ratio is inversely correlated with age of onset, and may be the sole factor in the development of heart failure in early onset patients, while it may have a synergistic effect on heart failure with anemia and renal dysfunction in late-onset patients.