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SPOP and FOXA1 mutations are associated with PSA recurrence in ERG wt tumors, and SPOP downregulation with ERG-rearranged prostate cancer.

Silvia Hernández-LlodràLaura SegalésAinara SafontNuria JuanpereMarta LorenzoLluís FumadóAlejo Rodríguez-VidaLluís CecchiniJoaquim BellmuntJosep Lloreta-Trull
Published in: The Prostate (2019)
In conclusion, SPOP and FOXA1 mutations may have prognostic value in ERG wt tumors. Interestingly, in absence of SPOP mutations, downregulation of this gene is a feature of many ERG-rearranged prostate tumors.
Keyphrases
  • prostate cancer
  • radical prostatectomy
  • signaling pathway
  • machine learning
  • genome wide
  • dna methylation
  • transcription factor
  • genome wide identification