Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19.
Julika NeumannTeresa PrezzemoloLore VanderbekeCarlos P RocaMargaux GerbauxSilke JanssensMathijs WillemsenOliver BurtonPierre Van MolYannick Van Hercknull nullJoost WautersEls WautersAdrian ListonStephanie Humblet-BaronPublished in: Clinical & translational immunology (2020)
As IL-10-secreting regulatory T cells are known to possess anti-inflammatory properties in the lung, their proportional increase could contribute to a more severe COVID-19 phenotype. We openly provide annotated data (https://flowrepository.org/experiments/2713) with clinical correlates as a systems immunology resource for the COVID-19 research community.