Water-Soluble Chitosan Conjugated DOTA-Bombesin Peptide Capped Gold Nanoparticles as a Targeted Therapeutic Agent for Prostate Cancer.
Theeranan TangthongThananchai PiroonpanVelaphi C ThipeMenka KhoobchandaniKavita KattiKattesh V KattiWanvimol PasanphanPublished in: Nanotechnology, science and applications (2021)
The AuNPs-WSCS-DOTA-BBN displayed cytotoxicity effects against PC-3 and LNCaP cancer cells, with concomitant safety toward the HAECs normal cells. The AuNPs-WSCS-DOTA-BBN showed synergistic targeting toward tumor cells with selective cytotoxicity of AuNPs towards PC-3 and LNCaP cells. Our investigations provide compelling evidence that AuNPs functionalized with WSCS-DOTA-BBN is an innovative nanomedicine approach for use in molecular imaging and therapy of GRP receptor-positive tumors. The template synthesis of AuNPs-WSCS-DOTA-BBN serves as an excellent non-radioactive surrogate for the development of the corresponding 198AuNPs theragnostic nanoradiopharmaceutical for use in cancer diagnosis and therapy.
Keyphrases
- pet ct
- pet imaging
- induced apoptosis
- prostate cancer
- cancer therapy
- water soluble
- cell cycle arrest
- endoplasmic reticulum stress
- drug delivery
- radical prostatectomy
- computed tomography
- signaling pathway
- stem cells
- cell death
- photodynamic therapy
- molecularly imprinted
- hyaluronic acid
- bone marrow
- high resolution
- mesenchymal stem cells
- childhood cancer
- smoking cessation
- silver nanoparticles
- pi k akt