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Metformin Suppresses Both PD-L1 Expression in Cancer Cells and Cancer-Induced PD-1 Expression in Immune Cells to Promote Antitumor Immunity.

Su Hwan ParkJuheon LeeHye Jin YunSeok-Ho KimJong-Ho Lee
Published in: Annals of laboratory medicine (2024)
Metformin blocks both PD-L1 and PD-1 within the tumor microenvironment. This study provided a mechanistic insight into the efficacy of metformin in improving immunotherapy in human cancer.
Keyphrases
  • papillary thyroid
  • squamous cell
  • high glucose
  • diabetic rats
  • oxidative stress
  • drug induced