In Vivo Evaluation of Dendropanax morbifera Leaf Extract for Anti-Obesity and Cholesterol-Lowering Activity in Mice.
Ji-Hye SongHyunhee KimMinseok JeongMin Jung KongHyo-Kyoung ChoiWoojin JunYongjae KimKyung-Chul ChoiPublished in: Nutrients (2021)
Metabolic syndrome is a worldwide health problem, and obesity is closely related to type 2 diabetes, cardiovascular disease, hypertension, and cancer. According to WHO in 2018, the prevalence of obesity in 2016 tripled compared to 1975. D. morbifera reduces bad cholesterol and triglycerides levels in the blood and provides various antioxidant nutrients and germicidal sub-stances, as well as selenium, which helps to remove active oxygen. Moreover, D. morbifera is useful for treating cardiovascular diseases, hypertension, hyperlipidemia, and diabetes. Therefore, we study in vivo efficacy of D. morbifera to investigate the prevention effect of obesity and cholesterol. The weight and body fat were effectively reduced by D. morbifera water (DLW) extract administration to high-fat diet-fed C57BL/6 mice compared to those of control mice. The group treated with DLW 500 mg∙kg-1∙d-1 had significantly lower body weights compared to the control group. In addition, High-density lipoprotein (HDL) cholesterol increased in the group treated with DLW 500 mg∙kg-1∙d-1. The effect of DLW on the serum lipid profile could be helpful to prevent obesity. DLW suppresses lipid formation in adipocytes and decreases body fat. In conclusion, DLW can be applied to develop anti-obesity functional foods and other products to reduce body fat.
Keyphrases
- high fat diet induced
- insulin resistance
- metabolic syndrome
- type diabetes
- high fat diet
- cardiovascular disease
- weight loss
- weight gain
- adipose tissue
- high density
- skeletal muscle
- low density lipoprotein
- glycemic control
- oxidative stress
- blood pressure
- squamous cell carcinoma
- coronary artery disease
- cardiovascular risk factors
- body mass index
- uric acid
- healthcare
- risk factors
- health information
- signaling pathway