Optimal PD-L1-high cutoff for association with overall survival in patients with urothelial cancer treated with durvalumab monotherapy.

Magdalena ZajacJiabu YePralay MukhopadhyayXiaoping JinYong BenJoyce AntalAshok K GuptaMarlon C RebelattoJ Andrew WilliamsJill Walker

Published in: PloS one (2020)

These findings support the utility of a combined TC/IC algorithm for predicting response to durvalumab in patients with UC, with the TC≥ 25%/IC≥ 25% cutoff optimal when used with the VENTANA (SP263) IHC Assay.

Keyphrases

papillary thyroid
machine learning
squamous cell
high throughput
deep learning
high grade
combination therapy
open label
urinary tract
lymph node metastasis
free survival
squamous cell carcinoma
neural network
newly diagnosed
single cell