Association between Cystic Fibrosis exacerbations, lung function, T2 inflammation and microbiological colonization.

Dana AlbonLijia ZhangJames PatrieMarieke JonesZ Galvin LiEmily NoonanLarry Borish

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2023)

This study has shown that in CF patients, T2 inflammation based on serum AEC and IgE correlated with pulmonary exacerbations requiring hospitalizations and/or intravenous antibiotics, independent of bacterial airway colonization. In addition, lung function decline correlated with increased IgE and AEC. Further studies are needed to explore these correlations and potential impact on treatment.

Keyphrases

lung function
cystic fibrosis
chronic obstructive pulmonary disease
pseudomonas aeruginosa
oxidative stress
end stage renal disease
ejection fraction
air pollution
prognostic factors
peritoneal dialysis
climate change
case control