Tumor Mutational Burden by Whole-Genome Sequencing in Resected NSCLC of Never Smokers.
Louis-Jacques RuelZhonglin LiNathalie GaudreaultCyndi HenryVictoria Saavedra ArmeroDominique K BoudreauTongwu ZhangMaria Teresa LandiCatherine LabbéChristian CouturePatrice DesmeulesPhilippe JoubertYohan BossePublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2022)
TMB is a prognostic indicator of survival in resected NSCLC from individuals who never smoked. In this setting of low mutation counts, TMB can be accurately measured by WGS or WES, but not NGS panels.