Hafnium-Based Metal-Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer.
Wei ZhouZhulong LiuNana WangXue ChenXiaozheng SunYufeng ChengPublished in: ACS omega (2022)
Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high Z elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simple one-step method for the synthesis of UiO-66-NH 2 (Hf) metal-organic framework nanoparticles for use as radiosensitizers in radiotherapy. The UiO-66-NH 2 (Hf) nanoparticles had a diameter of less than 100 nm and were stable in the physiological environment. UiO-66-NH 2 (Hf) induced apoptosis by enhancing X-ray absorption, as confirmed by in vitro and in vivo experiments. These characteristics make UiO-66-NH 2 (Hf) a promising radiosensitizer for esophageal cancer radiotherapy.
Keyphrases
- metal organic framework
- early stage
- locally advanced
- induced apoptosis
- radiation induced
- radiation therapy
- high resolution
- room temperature
- acute heart failure
- endoplasmic reticulum stress
- dual energy
- squamous cell carcinoma
- rectal cancer
- photodynamic therapy
- electron microscopy
- heart failure
- mass spectrometry
- ionic liquid
- optical coherence tomography